Our laboratory focuses on the pathogenesis of bacterial sexually transmitted diseases, with an emphasis on the host-pathogen interactions between Haemophilus ducreyi, which causes chancroid, and the human host.
The laboratory focuses on mechanisms regulating growth, survival differentiation, and homing/mobilization of hematopoietic stem and progenitor cells and embryonic stem cells at cellular, intracellular, and animal levels. It also focuses on immune activity and differentiation of T-lymphocytes, monocytes, and dendritic cells.
Dr. Capitano’s research focuses on discovering potential new agents that regulate hematopoietic stem and progenitor cell migration, proliferation, differentiation and survival capacity under normal and stressed conditions.
Chlamydia trachomatis infections are major causes of several sexually transmitted diseases and are prevalent in both industrialized and developing countries. The epithelial cells lining the reproductive tract are the major cell type productively infected with C. trachomatis, and the emphasis of our research will be to investigate the contribution of the infected epithelial cells to host defense.
Our laboratory focuses on the viral pathogenesis of hepatitis B virus and antiviral discovery.
My long term research interests include understanding immunological responses to the invasion of pathogens and tumors, and how modern lifestyle alters the immune system.
Chlamydial pathogenesis and interactions of pathogens and commensal microorganisms in the urogenital tract
My research focuses on understanding mechanisms that regulate normal and stressed hematopoietic stem and progenitor proliferation, differentiation and survival, and the role played by bone marrow niche support cells in hematopoietic stem cell function.
Dr. Yang's laboratory focuses on the gene regulation and pathogenesis of Borrelia burgdorferi, the causative agent of Lyme disease.
Immune responsiveness in humans and its role in protective immunity to tumors and pathogens as well as susceptibility to autoimmune disease.
The Brutkiewicz laboratory studies immune evasion by viruses and tumors, as well as the regulation of antigen presentation by various signal transduction pathways, in both innate and adaptive immune responses.
My laboratory is interested in the immune response to pathogens, allergy, inflammation, autoimmune disease, and vaccine development. We study T helper cell differentiation and the antibody response, and we are particularly interested in regulation of lymphocyte responses by the transcription factor BCL6.
The Gilk Lab studies manipulation of host cell lipids and lipid signaling by the intracellular bacterial pathogen Coxiella burnetii.
My laboratory has two main areas of focus. In the first, we are studying how chromatin structure regulates the expression of the PU.1 gene. The second area of focus began as studies on the regulation of TAP gene expression in macrophages. The Tap-1 and Tap-2 genes encode proteins which form a heterodimer that functions as a peptide transporter.
Our research focus is to define the metabolic vulnerabilities that can be exploited to develop an effective therapy for melanoma.
To identify mechanisms of action of stem cell mobilizers that will lead to safer and faster isolation of blood stem cells that can be used to cure leukemia and other cancers; to understand the role of the inhibitor of apoptosis family of proteins in normal and cancer biology.
The Spinola laboratory focuses on how the bacterium Haemophilus ducreyi successfully infects humans. We are specifically interested in differential human susceptibility to H. ducreyi infection and regulatory systems that control bacterial adaptation to the human host. The laboratory is also pursuing novel approaches for antimicrobial drug development.
Dr. Yu's laboratory mainly focuses on the immunopathology of HIV infection, and the clinical and immunological interactions between HIV and other human persistent viruses like HCV.
Mechanism of human papillomavirus induced malignancies. Development of novel antiviral drugs. Mechanism of p53 tumor suppression. Gene expression, DNA replication, DNA splicing. Pathogenesis of spinal muscular atrophy and development of therapy for SMA
I am engaged in the study of the clinical and molecular epidemiology of sexually transmitted infections, focused both on specific pathogens (Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis) and syndromes (urethritis in men).
Dr. Clapp's laboratory focuses on Nf1 tumor suppressor genes, inflammation, gene transfer.
Dr. Cornetta's laboratory focuses on retroviral vectors, gene transfer/gene therapy.
A major focus of ongoing projects in Dr. Fife's laboratory is on interactions between human papillomaviruses (HPV's) and the cells they infect.
Dr. Haneline's laboratory focus is hematopoiesis; role of Fanconi anemia proteins in protecting hematopoietic stem cells from apoptosis and malignant transformation; gene transfer/gene therapy.
Dr. John’s lab investigates malaria immunoepidemiology, the pathogenesis of severe malaria, and interactions between malaria and other disease states like iron deficiency and sickle cell disease.
Dr. Kaplan's laboratory focus is regulation of T helper cell differentiation and gene expression by transcription factors; inflammatory diseases; asthma and allergic diseases.
Hematopoietic stem cell transplantation, T cell biology, graft-versus-host disease, cytokines and cellular pathway networks, human immunology, translational medicine
We study the regulation of gene expression in a protozoan parasite called Toxoplasma gondii.
Our laboratory focuses on the cell biology of the intracellular parasite Toxoplasma gondii. In specific with aim at identifying the proteins and events involved in how the parasite enters and exits its host cell and how it survives the sudden physiological changes it encounters.
Dr. Brown's laboratory focuses on human papillomaviruses and the epidemiology of HPV infections.
To identify mechanisms in control of angiogenesis and blood vessel repair
We are committed to understanding basic aspects of oncogene function, which should lead to novel therapeutic approaches for difficult-to-treat cancers.
Dr. Gardner's laboratory focus is cancer, gene therapy; discovery, development, modification, and testing of tumor-specific promoters and novel delivery mechanism.
Dr. Ivan's laboratory aims to understand the role of specific microRNAs in the hypoxia response and in the progression of breast cancer.
Dr. Kao's laboratory focus is tissue/tumor-specific promoter-based gene therapy.
My laboratory investigates molecular mechanism(s) of adhesion/migration and growth control in normal and leukemic stem/progenitor cells, mast cells and erythroid cells.
Dr. Srour's laboratory focus is the characterization and biology of human hematopoietic stem cells; transplantation.
Dr. Zhou's laboratory focus is the mechanistic studies of pathogenesis of asthma and allergy. The roles of the cytokine TSLP on T cell subsets and allergic disease.