Jianyun (Jean) Liu, Ph.D.
Assistant Research Professor
Summary of the focus of the research of Dr. Jianyun Liu
My long term research interests include understanding immunological responses to the invasion of pathogens and tumors, and how modern lifestyle alters the immune system.
Description and summary of research focus of the laboratory
Modern lifestyle and diet not only contribute to the global epidemic of obesity, but also change the diversity of microbiota. It is not clear how altered microbiota in obesity link to chronic inflammation. Mucosal-associated innate T (MAIT) cells are recently identified innate T cells, and their development and maturation require commensal bacteria and MR1, the antigen presenting molecule for MAIT cells. MAIT cells are similar in some ways to another innate T cells that have been well-studied in our laboratory, Natural Killer T (NKT) cells. MAIT cells are significantly reduced in obese patients. Bacteria-derived vitamin B metabolites have been identified as the antigens that activate MAIT cells. We will study how MR1 molecules are processed and loaded with bacterial antigens in antigen presenting cells (APCs) before they reach the cell surface to activate MAIT cells. The goal is to understand the impact of obesity on MAIT cell function and its application in obesity-related diseases.
- Iyer AK, Liu J, Gallo RM, Kaplan MH, Brutkiewicz RR. (2015) STAT3 promotes CD1d-mediated lipid antigen presentation by regulating a critical gene in glycosphingolipid biosynthesis. Immunology 146 (3): 444-55 PMCID: PMC4610633
- Walline CC1, Deffit SN, Wang N, Guindon LM, Crotzer VL, Liu J, Hollister K, Eisenlohr LC, Brutkiewicz RR, Kaplan MH, Blum JS. Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy. Immunology 141(4):531-9. PMID: 24205828
- Gourapura, R.J., Khan, M.A., Gallo, R.M., Shaji, D., Liu, J., Brutkiewicz, R.R. Forming a complex with MHC class I molecules interferes with mouse CD1d functional expression. PLoS One 8(8):e72867, 2013. PMID: 24009709
- Liu J, Glosson NL, Du W, Gervay-Hague J; Brutkiewicz RR (2013) A Thr/Ser dual residue motif in the cytoplasmic tail of human CD1d is important for the down-regulation of antigen presentation following an HSV-1 infection. Immunology 140:191-201, 2013. PMCID: PMC3784165.
- Zeng MY, Pham D, Bagaitkar J, Liu J, Otero K, Shan M, Wynn TA, Brombacher F, Brutkiewicz RR, Kaplan MH, Dinauer MC (2013) An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD. Blood 2013 Apr 25:121(17):3473-83. PMID:23426944
- Gallo RM, Khan MA, Shi J, Kapur R, Wei L, Bailey JC, Liu J, Brutkiewicz RR (2012) Regulation of the actin cytoskeleton by rho kinase controls antigen presentation by CD1d. J Immunol.189(4):1689-98 PMCID: PMC3411863.
- Liu, J, Renukaradhya, G.J., Brutkiewicz, R.R. The Regulation of CD1d+ and CD1d- Tumors by NKT Cells. An invited book chapter in, “Natural Killer T cells: Balancing the Regulation of Tumor Immunity”. M. Terabe and J. Berzofsky, editors. Springer, New York, 2011.
- Liu J, Shaji D, Cho S, Du W, Gervay-Hague J, Brutkiewicz RR (2010) A threonine-based targeting signal in the human CD1d cytoplasmic tail controls its functional expression. J Immunol.184 (9):4973-81 PMCID: PMC2858764.
- 1998 B.S. Lanzhou University, Lanzhou, China
- 2006 Ph.D Virginia Polytechnic Institute and State University, Blacksburg, Virginia
- 2012 Postdoctoral Indiana University, School of Medicine, Indianapolis, Indiana