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Maegan Capitano, Ph.D.

Assistant Research Professor

Summary of the focus of the research of Dr. Capitano.

Dr. Capitano’s research focuses on discovering potential new agents that regulate hematopoietic stem and progenitor cell migration, proliferation, differentiation and survival capacity under normal and stressed conditions.

 

Description and summary of my research focus.

Dr. Capitano’s research focuses on how certain environmental conditions, cytokines and endogenous molecules (i.e. danger signals) induced during inflammation may affect hematopoiesis with the ultimate goal of understanding how these danger signals stimulate/regulate the proliferation and differentiation of hematopoietic stem and progenitor cells.  One protein that is of particular interest is DEK, a newly recognized danger signal that is implicated in the regulation of transcription, chromatin remodeling and mRNA processing  and that may help in maintaining hematopoietic stem cell numbers during inflammation.  Dr. Capitano’s research focuses on discovering whether DEK, which is secreted by bone marrow-derived macrophages or by T cells following inflammatory stimuli, plays a role in the resolution of inflammation thus preserving hematopoietic stem cell numbers and returning the bone marrow microenvironment to a more homeostatic level of hematopoiesis.

  • Broxmeyer, H. E., Capitano, M. L., Campbell, T. B., Hangoc, G., and Cooper, S. (2016)  Modulation of hematopoietic chemokine effects in vitro and in vivo by DPP4/CD26.  Stem Cells and Development.  25(8): 575-85. PMID: 26943017
  • Capitano, M. L. and Broxmeyer, H. E. (2016) “CXCL12/SDF-1 and Hematopoiesis” Reference Module in Biomedical Sciences.  Encyclopedia of Cell Biology.  Waltham & Oxford. Elsiever Publishing. (Eds. Bradshaw, R.A. and Stahl, P.D.) Volume 3; pp. 624-631.
  • Capitano, M. L., Chitteti, B. R., Cooper, S., Srour, E. F., Bartke, A., & Broxmeyer, H. E. (2015)  Ames hypopituitary dwarf mice demonstrate imbalanced myelopoiesis between bone marrow and spleen.  Blood Cells, Molecules, and Diseases. 55(1), 15-20.  PMID: 25976461
  • Capitano, M. L., Hangoc, G., Cooper, S., & Broxmeyer, H. E. (2015)  Mild heat treatment primes human CD34+ cord blood cells for migration towards SDF-1? and enhances engraftment in an NSG mouse model.  Stem Cells. 33(6):1975-1984.  PMID: 25753525
  • Broxmeyer, H. E., Mor-Vaknion, N., Kappes, F., Legendre, M., Saha, A. K., Ou, X., O’Leary, H., Capitano, M., Cooper, S., & Markovitz, D. M. (2013).  Concise review: role of DEK in stem/progenitor cell biology.  Stem Cells. 31(8), 1447-1453.  PMID: 23733396
  • Kokolus, K. M.*, Capitano, M. L.*, Lee, C.-T., Eng, J. W., Waight, J. D., Hylander, B. L., Sexton, S., Hong, C. C., Gordon, C. J., Abrams, S. I., & Repasky, E. A.  (2013)  Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature.  Proceedings of the National Academy of Science USA.  110(50), 20176-20181.  *, These authors contributed equally to this work.  PMID: 24248371
  • Bian, G., Ding, X., Leigh, N. D., Tang, Y., Capitano, M. L., Qiu, J., McCarthy, P. L., Liu, H., & Cao, X. (2012). Granzyme B-Mediated Damage of CD8+ T Cells Impairs Graft-versus-Tumor Effect.  Journal of Immunology, 190(3), 1341-1350. PMID: 23264653
  • Capitano, M. L., Nemeth, M.  J., Mace, T. A., Salisbury-Ruf, C., Segal, B. H., McCarthy, P. L., & Repasky, E. A. (2012). Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1, IL-17, and G-CSF dependent manner. Blood, 120(13), 2600-2609. PMID: 22806894
  • Sen, A., Capitano, M. L., Spernyak, J. A., Schueckler, J. T., Thomas, S., Singh, A. K., Evans, S. S., Hylander, B. L., & Repasky, E. A.  (2011). Mild elevation of body temperature reduces tumor interstitial fluid pressure and hypoxia and enhances efficacy of radiotherapy in murine tumor models. Cancer Research, 71(11), 3872-3880. PMID: 21512134
  • Capitano, M. L., Ertel, B. R., Repasky, E. A., & Ostberg, J. R. (2008) Winner of the 2007 Society for Thermal Medicine Young Investigator Award: Fever-range whole body hyperthermia prevents the onset of type 1 diabetes in non-obese diabetic mice. International Journal of Hyperthermia, 24(2): 141-149. PMID: 18283590
  • B.A., 2004: St. Mary’s Honors College of Maryland
  • M.S., 2006: State University of New York at Buffalo, Roswell Park Cancer Institute Division
  • Ph.D., 2012: State University of New York at Buffalo, Roswell Park Cancer Institute Division
  • Post-Doctoral Fellowship, 2012-2016: Indiana University School of Medicine
  • Assistant Research Professor, 2016-Current: Indiana University School of Medicine, Department of Microbiology and Immunology

Department of Microbiology and Immunology | IU School of Medicine | 635 Barnhill Drive, MS 420 | Indianapolis, IN 46202 | (317) 274-0506