Chandy John, M.D.
Ryan White Professor
Professor of Department of Pediatrics, Department of Microbiology & Immunology & Department of Medicine
Summary of the focus of the research of Dr. John
Dr. John’s lab investigates malaria immunoepidemiology, the pathogenesis of severe malaria, and interactions between malaria and other disease states like iron deficiency and sickle cell disease.
Description and summary of Dr. John's research focus
The John Lab is a collaborative research group that conducts research at Indiana University and in Uganda (with Makerere University) and Kenya (with the Kenya Medical Research Institute and Maseno University).
The John Lab focuses on six major questions related to malaria:
- Which host and pathogen factors contribute to development of severe malaria?
- How does the immune response to malaria contribute to long-term neurodevelopmental impairment in children with severe malaria?
- How can iron deficiency be safely treated in malaria endemic areas?
- What contributes to the increased risk of death from malaria in children with sickle cell disease?
- How do changing transmission conditions affect development of immunity in malaria?
- What the environmental predictors of malaria risk in epidemic-prone areas?
- Shabani E, Opoka RO, Idro R, Schmidt R, Park GS, Bangirana P, Vercellotti GM, Hodges JS, Widness JA, John CC. High plasma erythropoietin levels are associated with prolonged coma duration and increased mortality in children with cerebral malaria. Clin Infect Dis. 2015 Jan 1;60(1):27-35. PMCID pending.
- Frosch AE, Ondigo BN, Ayodo GA, Vulule JM, John CC, Cusick SE. Decline in childhood iron deficiency after interruption of malaria transmission in highland Kenya. Am J Clin Nutr. 2014 Sep;100(3):968-73. PMCID pending
- Ochola LA, Ayieko C, Kisia L, Magak NG, Shabani E, Ouma C, John CC. Changes in antigen-specific cytokine and chemokine responses to Plasmodium falciparum antigens in a highland area of Kenya after prolonged absence of malaria exposure. Infect Immun. 2014 Sep;82(9):3775-82. PMCID: PMC4187839
- Bangirana P, Opoka RO, Boivin MJ, Idro R, Hodges JS, Romero RA, Shapiro E, John CC. Severe malarial anemia is associated with long-term neurocognitive impairment. Clin Infect Dis 2014 Aug;59(3):336-44. PMCID: PMC4155441.
- Ondigo BN, Hodges JS, Ireland KF, Magak NG, Lanar DE, Dutta S, Narum DL, Park GS, Ofulla AV, John CC. Estimation of recent and long-term malaria transmission in a population by antibody testing to multiple Plasmodium falciparum antigens. J Infect Dis. 2014 Oct 1;210(7):1123-32. PMCID: PMC4168304.
- Ayieko C, Maue AC, Jura WG, Noland GS, Ayodo G, Rochford R, John CC. Changes in B Cell Populations and Merozoite Surface Protein-1-Specific Memory B Cell Responses after Prolonged Absence of Detectable P. falciparum Infection. PLoS One. 2013 Jun 27;8(6):e67230. Print 2013. PMCID: PMC3695086.
- Moormann AM, Sumba PO, Chelimo K, Fang H, Tisch DJ, Dent AE, John CC, Long CA, Vulule J, Kazura JW. Humoral and cellular immunity to Plasmodium falciparum merozoite surface protein 1 and protection from infection with blood-stage parasites. J Infect Dis. 2013 Jul;208(1):149-58. PMCID: PMC3666139
- Ondigo BN, Park GS, Gose SO, Ho BM, Ochola LA, Ayodo GO, Ofulla AV, John CC. Standardization and validation of a cytometric bead assay to assess antibodies to multiple Plasmodium falciparum recombinant antigens. Malar J. 2012 Dec 21;11(1):427. PMCID: PMC3546950
- Park GS, Ireland KF, Opoka RO, John CC. Evidence of Endothelial Activation in Asymptomatic Plasmodium falciparum Parasitemia and Effect of Blood Group on Levels of von Willebrand Factor in Malaria. J Ped Inf Dis 2012; 1(1):16-25. PMCID: 3656549.
- Noland GS, Ayodo G, Abuya JS, Hodges JS, Rolfes MAR, John CC. Decreased prevalence of anemia in highland areas of low malaria transmission after a one-year interruption of transmission. Clinical Infectious Diseases 2012; 54(2):178-84. PMCID: PMC3245725
- Professor of Pediatrics, Microbiology and Immunology, 2015-Present, Indiana University
- Adjunct Professor of Pediatrics, 2015-Present, University of Minnesota
- Adjunct Professor of Epidemiology, 2011-2014, University of Minnesota
- Professor of Pediatrics and Medicine, 2010-2014, With Tenure, University of Minnesota Director, Division of Global Pediatrics, 2005-Present, University of Minnesota
- Associate Professor of Pediatrics and Medicine, 2005-2010, With Tenure, University of Minnesota
- M.S., 2001, Case Western Reserve University
- Assistant Professor of Pediatrics and International Health, 1999-2005, Case Western Reserve University and Rainbow Babies & Children’s Hospital
- Pediatric Infectious Diseases Fellowship, 1995-1998, Case Western Reserve University
- Internal Medicine and Pediatrics Residency, 1998-1992, University of Michigan; Ann Arbor, MI
- M.D., cum laude eruditionis causa, 1988, University of Michigan Medical School
- B.S., 1986, University of Michigan