Kenneth G. Cornetta, M.D.
Adjunct Professor, Department of Medical & Molecular Genetics
Adjunct Professor of Microbiology & Immunology
Description and summary of research focus of the laboratory
Dr. Cornetta's laboratory is interested in the use of gene transfer in the treatment of human malignancies. The laboratory is particularly interested in the development and use of retroviral and lentiviral (HIV-1) based vectors. Three areas of active research are being explored. The first aims to efficiently transduce human bone marrow progenitor cells from cancer patients with retroviral vectors expressing drug resistance genes. Their second area of research aims to develop tumor vaccines for breast cancer and leukemia that utilize vector technology. Lastly, the Indiana University Vector Production Facility, a designated NIH National Gene Vector Laboratory, is charged with generating clinical grade vector for human gene therapy trials. Research in this area aims to optimize and understand gene transduction gene expression, with emphasis on potential clinical applications.
- Abonour, R., Williams, D.A., Einhorn, L., Hall, K.M., Chen, J., Coffman, J., Traycoff, C.M., Bank, A., Kato, I., Ward, M., Williams, S.D., Hromas, R., Robertson, M.J., Smith, F.O., Woo, D., Mills, B., Srour, E.F., Cornetta, K. Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem. Nature Medicine 6:652-658, 2000.
- Cornetta, K. and Smith, F.O. Regulatory issues for clinical gene therapy trials. Human Gene Therapy 13:1143-1149, 2002.
- Duffy, L., Koop, S., Fyffe, J., and Cornetta, K. Extended S+/L- assay for detecting replication competent retroviruses pseudotyped with the RD114 viral envelope. Preclinica May/June:53-59, 2003.
- Sastry, L., Xu, Y., Johnson, T., Desai, K., Rissing, D., Marsh, J., and Cornetta, K. Certification assays for HIV1-based vectors: Frequent passage of gag sequences without evidence of replication competent viruses. Molecular Therapy 8:830-839, 2003.
- Kahl, C.A., Marsh, J., Fyffe, J., Sanders, D.A., and Cornetta, K. Human immunodeficiency virus type 1-derived lentivirus vectors pseudotyped with envelope glycoproteins derived from ross river virus and semliki forest virus. Journal of Virology 78:1421-1430, 2004.
- B.S. 1978 - State University of New York; Albany NY
- M.D. 1982 - Albany Medical College; Albany, NY