Utpal Dave, M.D.
Department of Medicine
Department of Microbiology & Immunology
Summary of the focus of the research of Dr. Dave
We are committed to understanding basic aspects of oncogene function, which should lead to novel therapeutic approaches for difficult-to-treat cancers.
Description and summary of your laboratory's research focus
We study two oncogenic pathways in the pathogenesis of T-cell leukemias and lymphomas. Collectively, the T-cell neoplasms are very resistant to current chemotherapy regimens; thus, we see an opportunity in establishing IU as a major referral center. We will bank tumor samples and apply genomic technologies, to help guide our therapeutic approaches (precision medicine). Our patients will lead us to think harder about these diseases and to generate new ideas.
- Bhuvaneshwar K, Sulakhe D, Gauba R, Rodriguez A, Madduri R, Dave U, Lacinski L, Forster I, Gusev Y, Madhavean S. A case study for cloud based high throughput analysis of NGS data using the globus genomics system. Comput Struct Biotechnol J 2014; Nov 7; 13:64-74.
- Tripplett TA, Cardenas KT, Lancaster JN, Hu Z, Selden HJ, Jasso GJ, Balasubramanyam S, Chan K, Li L, Chen X, Marcogliese AN, Dave UP, Love PE, Ehrlich LI. Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation. Proc Natl Acad Sci USA 2016; Feb 23, 113(8):E1016-25. doi: 10.1073/pnas.1520245113
- Layer JH, Alford CE, McDonald WH, Dave UP. LMO2 oncoprotein stability in T-cell leukemia requires direct LDB1 binding. Mol Cell Biol 2015 Nov 23;36(3):488-506.
- Sulakhe D, Xie B, Taylor A, D’Souza M, Balasubramanian S, Hashemifar S, White S, Dave UJ, Agam G, Xu J, Wang S, Gilliam TC, Maltsev N. Lynx: a knowledge base and an analytical workbench for integrative medicine. Nucleic Acids Res 2016 Jan 4;44(D1):D882-7. doi: 10.1093/nar/gkv1257
- McGirt LY, Jia P, Baerenwald DA, Duszynski RJ, Dahlman KB, Zic JA, Zwerner JP, Hucks D, Dave U, Zhao Z, Eischen CM. Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides. Blood 2015 Jul 23;126(4):508-19.
Post-doctoral Fellowship - University of Texas Southwestern Medical Center, Dallas, TX 12/2000
Post-doctoral Fellowship - NCI, National Institutes of Health, Bethesda, MD 10/2005
M.D. - Northwestern University Feinberg School of Medicine, Chicago, IL 06/1994