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Gene Transfer/Gene Therapy

Externally (NIH) Funded and Internally
Funded Interdisciplinary Programs

Training programs are available in the areas of Hematopoiesis, Gene Transfer/Gene Therapy, Immunology and Infectious Disease and Cancer Biologya Training Program for Medical Scientists (leading to the MD/PhD) is also available.

Gene Transfer/Gene Therapy Training Program

This training program supports 5 postdoctoral trainees (M.D. and/or Ph.D.) and 3 predoctoral students (M.D./Ph.D., or Ph.D.) per year has a strong emphasis on cell and molecular biology/immunology of gene therapy.  The competitive renewal of this grant was awarded. The average training period for postdoctoral and predoctoral students will be 3 and 4 years, respectively.   Twenty-one well established preceptors provide extensive training in highly active as well as interactive research laboratories pursuing state of the art research on fundamental aspects of cellular, molecular biological, and immunological aspects of a variety of human diseases, and the prospects of developing novel gene therapy approaches for some of these disorders. All of the preceptors are housed in newly built or renovated spacious laboratories in 4 basic science departments, 2 clinical departments, and in four research centers, with several cross-appointments, in four adjoining buildings. Major strengths of the training program include a strong track record of research on gene transfer/gene therapy, peer-reviewed publications and extramural funding of the preceptors, and the existence of an NIH-designated National Vector Laboratories on campus. Ample opportunities for pursuing multi-disciplinary research exist due to active, ongoing scientific collaborations among various preceptors. A significant emphasis is placed to promote and foster the development of the next generation of biomedical researchers committed to scientific careers in academic medicine to become independent investigators who, in turn, will themselves be productive and competitive. A multi-pronged approach for comprehensive training encompassing close and direct contact with preceptors, frequent, informal interactions with staff members, visiting scientists, formal and informal courses and seminars, laboratory meetings, and participation in national and international scientific meetings, is in place. The decision to associate with a laboratory will be by mutual consent of the trainee and the preceptor, and the scientific development of the trainee will be facilitated by a research committee composed of preceptors with multi-disciplinary research interests. Major resources that are available include internationally recognized clinical and basic science research programs, state of the art infra-structure, and frequent contacts with active investigators within and outside of Indiana University.

Predoctoral and postdoctoral students interested in being considered for these competitive stipends should contact Hal E. Broxmeyer, Ph.D., the Program Director at hbroxmey@iupui.edu. The preceptors and affiliations are listed below.

Broxmeyer, Hal E., Ph.D.

IU Sch. of Med.; Micro/Immun; Med; IUSCC; IC

Brutkiewicz, Randy B., Ph.D.

IU Sch. of Med.; Micro/Immun; IUSCC; IC

Clapp, Wade D., M.D.

IU Sch. of Med.; Ped; Micro/Immun; WCPR; IUSCC

Cornetta, Kenneth, M.D.

IU Sch. of Med.; Med/Mol. Genet; Micro/Immun; IUSCC

Dent, Alex, Ph.D

IU Sch. of Med.; Micro/Immun; IUSCC; IC

Field, Loren J., Ph.D.  IU School of Med.;
Haneline, Laura, M.D. IU Sch. of Med.; Pediatrics;WCPR; IUSCC

Herbert, Brittney-Shea, Ph.D.

IU Sch. of Med.; Med/Mol Genet

Ingram, David A., M.D.

IU Sch. of Med.; Ped

Kao, Chinghai, Ph.D.

IU Sch. of Med.; Micro/Immun; Urol; IUSCC

Kaplan, Mark H., Ph.D.

IU Sch. of Med.; Micro/Immun; IUSCC; IC

Kapur, Reuben, Ph.D.  IU Sch. of Med.; Ped; Micro/Immun; Biochem

Kelley, Mark R., Ph.D.

IU Sch. of Med.; Ped; Biochem/Mol. Biol; WCPR; IUSCC

Lee, Suk-Hee, Ph.D.

IU Sch. of Med.; Biochem/Mol. Biol; IUSCC

 Morral, Nuria, Ph.D.  Med/Mol Genet; Biochem

Nakshatri, Harikrishna, Ph.D.

 IU Sch. of Med.; Surg., IUSCC
Orschell, Christie M., Ph.D.  IU Sch. of Med

Pelus, Louis M., Ph.D.

IU Sch. of Med.; Micro/Immun; IUSCC

Quilliam, Lawrence A., Ph.D.  IU Sch. of Med.;Biochem/Mol. Biol.; IUSCC

Srour, Edward F., Ph.D.

IU Sch. of Med.; Med; Ped; Micro/Immun; WCPR; IUSCC

Yoder, Mervin C., M.D. IU Sch. of Med.; Peds.; IUSCC

Zhang, Jian-Ting, Ph.D.

IU Sch. of Med.; Pharm/Tox; IUSCC

PERFORMANCE SITES: Indiana University School of Medicine (IU Sch of Med); Indianapolis, Indiana; Microbiology and Immunology (Micro/Immun); Pediatrics (Ped); Medicine (Med); Pharmacology and Toxicology (Pharm/Tox); Biochemistry and Molecular Biology (Biochem/Mol., Biol); Medical and Molecular Genetics (Med/Mol Genet.); CENTERS:  Wells Center for Pediatric Research (WCPR); Immunobiology Center (IC);   IU Cancer Center (IUCC)

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Department of Microbiology and Immunology | IU School of Medicine | 635 Barnhill Drive, MS 420 | Indianapolis, IN 46202 | (317) 274-0506