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Ingraham Lecture

THE INGRAHAM IMMUNOLOGY SEMINAR SERIES

Established to Honor and Recognize the Many Contributions of

DR. JOSEPH STERLING INGRAHAM

(1920-1997)

PROFESSOR EMERITUS OF MICROBIOLOGY AND IMMUNOLOGY

INDIANA UNIVERSITY SCHOOL OF MEDICINE

Joseph S. Ingraham was born November 13, 1920 in Grand Rapids, Minnesota. He completed his undergraduate studies at the University of Minnesota, where he received a Bachelor of Sciences degree in Chemistry in 1943. Accepting a position as a research chemist at the Armor Co. in Chicago, Joe Ingraham assisted with studies leading to several patents on protein by-products. He enrolled the graduate program at the University of Chicago in 1946 and subsequently received his M.S. in 1947 and his Ph.D. in biochemistry in 1950. Working with his faculty mentor, Professor James Moulder, Joe focused on the synthesis of a radioactive, chemically defined antigen. These investigators would lead to Joe's life-long interest in immunology.

Continuing his research at the U. of Chicago for another four years, Joe joined the Indiana University faculty as an Assistant Professor of Microbiology in the School of Medicine in 1954. While his first efforts focused on establishing his research program, Joe had a keen interest in graduate education. Joe was instrumental in the development of the departmental graduate training program, and he worked diligently towards awarding of the first doctoral degree to a graduate student in 1957. During his initial years on the faculty, he organized an outstanding graduate course in Immunochemistry which included formal lectures and laboratory exercises. For the next thirty years, Joe would serve as director or co-director of this popular course. A natural teacher, Joe excelled at working with students one-on-one in the laboratory as well as in the classroom. Joe's enthusiasm stimulated new and seasoned trainees to think carefully about scientific problems, to formulate questions and hypothesis, and to analyze data with precision. Joe engaged students in a variety of venues including serving as an active instructor for many medical and nursing students throughout his career at Indiana University. He worked purposefully to share his interests in science and medicine with students, as well as conveying his principles for interpreting scientific data, research ethics, and a focus on high standards for laboratory work.

By 1960, Joe's research team was actively engaged in defining the kinetics of antibody-antigen interactions, resulting in several important research publications. These studies involved precise measurements of serum of antibodies following antigenic stimulation of animals. Their results suggested that the induction of these humoral immune responses was linked to events mediated by immune cells. Yet at that time, there was no procedure available to detect antibody formation by single cells. Joe and his team devoted much effort to the problem, and in 1961 he conceived a means to isolate cells in the process of secreting antibodies. During a sabbatical leave at the Pasteur Institute in Paris, he worked out the details of this new method. His methodology first published in 1963, along with a similar approached developed at that time by the Nobel Laureate Niels Jerne, provided an experimental basis for many subsequent observations elucidating the cellular activities of antibody secreting B lymphocytes, or plasma cells. Back in Indianapolis, Joe and his dedicated team of students used his approach technique to monitor dynamics of antibody formation, as documented in a series of elegant and novel papers on the genetic restriction of antibody specificity.

Joe hosted many international visitors and colleagues in Indianapolis, given his many scientific discoveries and his keen sense of collaboration and congenial nature. Students and faculty colleagues benefited from these visits via the opportunity to meet many talented scientists and numerous outstanding seminars on topics related to immunology. He shared his expertise as a member of many important scientific societies including: The American Chemical Society, The American Association of Immunologists, The American Society for Microbiology, Societe Francaise d' Immunologie, American Association for the Advancement of Science, Sigma Xi and the Indiana Academy of Science. In 1965, Joe was elected president of the campus chapter of Sigma Xi, the scientific honor society and in 1969 he served as president of the Indiana Branch of the American Society for Microbiology.

Joe's many contributions as an educator and a scientist continue to inspire and benefit many including his colleagues, friends and many past and present trainees within the Indianapolis community, Indiana University, and his beloved discipline of Immunology. We thank his many colleagues, former students and his family, including his beloved wife Ruth Ann Ingraham and his children Dr. Loring Joseph Ingraham and Mary Edith Ingraham for continuing to support Joe's desire to nourish training and research in Immunology at Indiana University. Through their generosity, an endowment was established which brings many talented and internationally recognized experts in Immunology to Indianapolis and the Indiana University School of Medicine. A list of the many outstanding scholars who have selected for the honor of participating in the Ingraham Seminar Series in Indianapolis is provided here.

Joseph S. Ingraham Classical Immunology Lecturers


1998

Bruce Merchant, M.D., Ph.D.,
President and Founder of Merchant-Taylor International, Inc.,
Biopharmaceutical Consulting Services,
San Diego, California
"From Biomedical Discovery To Patient Benefit: As Seen From Academic,
Regulatory and Commercial Perspectives"

 

2000

Chella David, Ph.D.
Alice Sheets Marriott Professor
Department of Immunology
Mayo Clinic and Medical School
Rochester, Minnesota
"Role of HLA DQ and DR Genes in Human Autoimmune Diseases:
Studies With Transgenic/Knockout Mice"

 

2002

Olivera J. Finn, Ph.D.
Professor and Chair
Department of Immunology
University of Pittsburgh School of Medicine
University of Pittsburgh Cancer Institute
Pittsburgh, Pennsylvania
"Epithelial Tumor Antigens and Cancer Vaccines"

 

2004

Fred Finkelman, M.D.
McDonald Professor of Medicine
Professor of Pediatrics and
Director of the Division of Immunology
University of Cincinnati School of Medicine
Cincinnati, Ohio
"When Good Antibodies Turn Bad: Lessons From Mouse Models of Anaphylaxis"

 

2006

Mitchell Kronenberg, Ph.D.
President and Scientific Director
Division of Developmental Immunology
La Jolla Institute for Allergy & Immunology
La Jolla, California
"Innate Immune Responses To Microbes By NKT Cells"

 

2009

Paul M. Allen, Ph.D.
Robert L. Kroc Professor
Department of Pathology and Immunology
Washington University School of Medicine
St. Louis, Missouri
"The Herculean Tasks of Developing T Cells"

 

2010

Joseph E. Craft, Ph.D.
Professor of Medicine and Immunobiology
Chief, Section of Rheumatology
Director, Investigative Medicine Program
Yale University School of Medicine
New Haven, Connecticut
"New insights into CD4 T Cell differentiation"

 

2013

Anuradha Ray, Ph.D.
Professor of Medicine and Immunology
Division of Pulmonary, Allergy, and Critical Care Medicine
University of Pittsburgh
Pittsburgh, Pennsylvania

 

2015

Marc K. Jenkins, Ph.D.
Distinguished McKingiht University Professor
Director, Center for Immunology, Department of Microbiology
University of Minnesota Medical School
Minneapolis, Minnesota


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